Integrating Psychosocial and Molecular Insights in Labor: Single-Cell Omics of Maternal Hematology and Doula-Assisted Births

Authors

  • Xinduo Gao Zhengzhou Urban Construction Vocational College, Zhengzhou Henan 451200, P.R. China Author
  • Liya Jiang Zhengzhou Urban Construction Vocational College, Zhengzhou Henan 451200, P.R. China Author
  • Xuezhen Lu Zhengzhou Urban Construction Vocational College, Zhengzhou Henan 451200, P.R. China Author
  • Jingjing Li Zhengzhou Urban Construction Vocational College, Zhengzhou Henan 451200, P.R. China Author
  • Yuan Xi Zhengzhou Urban Construction Vocational College, Zhengzhou Henan 451200, P.R. China Author
  • Huihui Jia Zhengzhou Urban Construction Vocational College, Zhengzhou Henan 451200, P.R. China Author
  • Lixia Zhang Department of Medical Nursing, Zhengzhou Urban Construction Vocational College, No. 6 Zhongyuan West Road, Zhengzhou 451200, China Author
  • Cheng Chang Department of Medical Nursing, Zhengzhou Urban Construction Vocational College, No. 6 Zhongyuan West Road, Zhengzhou 451200, China Author

DOI:

https://doi.org/10.64229/16g9x304

Keywords:

Single-Cell Transcriptomics, Maternal Immune Adaptation, Doula-Supported Birth, Hematological Regulation, Psychoneuroimmunology

Abstract

Psychosocial support during childbirth, particularly through doula-assisted care, has been shown to reduce maternal stress and improve obstetric outcomes, yet the underlying hematological and immunological mechanisms remain largely unexplored. Emerging single-cell technologies now enable unprecedented resolution in mapping maternal immune adaptations during labor. This review synthesizes current evidence on hematological and immune remodeling in parturition and proposes a framework for applying single-cell multi-omics to understand how doula-supported births may influence stress-related immune dynamics. By integrating insights from psychoneuroimmunology, hematology, and computational biology, we highlight potential molecular pathways linking emotional support to immune homeostasis and maternal recovery. Such interdisciplinary exploration may reveal novel biomarkers and therapeutic strategies for precision perinatal care.

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Published

2025-11-19

Issue

Vol. 1 No. 2 (2025)

Section

Articles

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Copyright (c) 2025 Xinduo Gao, Liya Jiang, Xuezhen Lu, Jingjing Li, Yuan Xi, Huihui Jia, Lixia Zhang, Cheng Chang (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Xinduo Gao, Liya Jiang, Xuezhen Lu, Jingjing Li, Yuan Xi, Huihui Jia, Lixia Zhang, & Cheng Chang. (2025). Integrating Psychosocial and Molecular Insights in Labor: Single-Cell Omics of Maternal Hematology and Doula-Assisted Births. Hematological Disorders in the Single-Cell Era, 1(2), 1-6. https://doi.org/10.64229/16g9x304